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KMID : 1145520230090010043
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Journal of Radiopharmaceuticals and Molecular Probes
2023 Volume.9 No. 1 p.43 ~ p.48
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In vivo Trafficking of Liposomes Containing Boron Compounds for Boron Neutron Capture Therapy (BNCT)
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Huu Bao Nguyen
Yoo Jeong-Soo
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Abstract
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For over 50 years, boron neutron capture therapy (BNCT) has been steadily developed for treating various cancers. This is a non-invasive, selective, and targeted radiotherapy wherein boron-rich molecules accumulate at the tumor site. Liposomal vesicles have become a popular and effective drug delivery system for BNCT, with strategies including surface decoration, bilayer integration, and hydrophilic core encapsulation. This review highlights the state-of-the-art uses of liposomes in BNCT and elucidates a new perspective where BNCT can be used with radiotracer guidance in all-in-one delivery systems.
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KEYWORD
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BNCT, Liposomes, Cancer, Radiotracers
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